Nephrotic Syndrome
Nephrotic syndrome is a
nonspecific disorder in which the kidneys are damaged, causing them to leak
large amounts of protein from blood and urine.
Classification
Nephrotic syndrome can be primary; being a disease specific to the kidneys or it can be secondary, being a renal
manifestation of a systemic general illness. In all cases, injury to glomeruli
is an essential feature.
Primary causes
of nephrotic syndrome include, in approximate order of frequency:
- Minimal change
nephropathy
- Focal
glomerulosclerosis
- Membranous
nephropathy
- Hereditary
nephropathy
Secondary
causes include, again in order of approximate frequency:
- Diabetes mellitus
- Lupus
erythematosus
- Viral infections
The symptoms of
nephrotic syndrome include:
- Foamy and frothy
urine
- Unexplained
weight loss
- General malaise
- Oedema,
particularly around the abdomen, legs and eyes
- Muscle wasting
- Stomach pain
- Dizziness when
standing up from a lying or sitting position (orthostatic hypotension).
Causes of
nephrotic syndrome
Changes to the
immune system – this type is most common in children. It is called ‘minimal
change’ because the kidney filters appear normal under a microscope. The cause
is thought to be changes in certain cells of the immune system. The function of
the kidneys is normal and the outlook for recovery is usually excellent.
Inflammation – local inflammation or swelling damages and scars
the kidney filters. Examples of this are focal glomerulosclerosis and
membranous nephropathy. Treatment may not resolve the condition and the kidneys
may gradually lose their ability to filter wastes and excess water from the
blood.
Secondary
nephrotic syndrome – can be caused by certain conditions including diabetes,
drugs, cancer and systemic lupus erythematosus (SLE).
Diagnosing
nephrotic syndrome involves a number of tests, including:
-Urine tests – excessive protein makes the urine appear frothy and foamy. A
dipstick urine test can also detect protein levels. A 24-hour urine collection
or a spot urine protein/creatinine ratio may be done if urine protein is found
on the dipstick. These tests measure the amount of protein more precisely and
identify whether kidney damage is mild, moderate or heavy.
-Blood tests – to check the blood protein and creatinine levels.
-Biopsy – a small sample of kidney tissue is taken and examined in a
laboratory.
-Ultrasound – an examination of the kidneys using sound waves to outline the
structure of organs.
-Computed tomography (CT) scan or magnetic resonance imaging (MRI)
- Autoimmune markers
Homoeopathic projection: -
Homeopathic
treatment for Nephrotic Syndrome has been found to be extremely effective.
- Homeopathic
treatment aims at reducing
a. Frequency of attacks
b. Severity and duration of attacks
c. Cortisone dependency
- It regulating
autoimmune processes
- It works by
controlling the protein leakage, by correcting the glomerular function.
- Correcting the
genetic tendencies
- It enhances
immunity whereby the frequent infections reduce drastically and hence the
attacks of Nephrotic Syndrome.
- Reducing the
frequency of episodes of Nephrotic Syndrome
- Reducing the
duration of subsequent episodes
- Reducing the
severity of episodes
- Reducing the
steroid dependency, whereby the patient should be able to manage with smaller
dose of steroids in the early stages and eventually be able to reduce it and
finally should be able to manage without steroids.